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Heinz, A

This leads to the disruption of adherens junctions, further impairing cell-cell adhesion and compromising the epithelial barrier, rendering host tissue susceptible to pathogen invasion

in dermatology are supported by several key aspects

doi: 10.3389/fncel.2016.00179 38

Interestingly, these mutations also associate with secondary mitochondrial dysfunction although their distinct contribution to diabetes development is uncertain in this context of protein misfolding (La Morgia et al., 2020)